Uroplakin-3a

UPK3A
Identifiers
Aliases	UPK3A, UP3A, UPIII, UPIIIA, UPK3, uroplakin 3A
External IDs	OMIM: 611559; MGI: 98914; HomoloGene: 5066; GeneCards: UPK3A; OMA:UPK3A - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	45,295,874 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	84,906,748 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; mucosa of urinary bladder; ; monocyte; ; prostate; ; muscle of thigh; ; granulocyte; ; muscle of arm; ; biceps brachii; ; skeletal muscle tissue; ; deltoid muscle;
	Top expressed in
	transitional epithelium of urinary bladder; ; Transitional epithelium of renal pelvis; ; transitional epithelium of ureter; ; medullary collecting duct; ; male urethra; ; epithelium of male urethra; ; right kidney; ; epithelium of female urethra; ; morula; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular exosome; endoplasmic reticulum membrane; apical plasma membrane; membrane; integral component of membrane; endoplasmic reticulum; apical plasma membrane urothelial plaque;
Biological process	kidney development; urea transport; epithelial cell differentiation; sodium ion homeostasis; potassium ion homeostasis; urinary bladder development; cell morphogenesis; water transport;
	Sources:Amigo / QuickGO
Orthologs
	7380
	22270
	ENSG00000100373
	ENSMUSG00000022435
	O75631
	Q9JKX8
	NM_001167574; NM_006953
	NM_023478
	NP_001161046; NP_008884
	NP_075967
	Wikidata
View/Edit Human	View/Edit Mouse

Uroplakin-3a (UP3a) is a protein that in humans is encoded by the UPK3A gene.^[5]^[6]

UP3a is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full.^[7] It is also found in the renal pelvis, ureter, and prostatic urethra.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100373 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022435 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y (Dec 1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma". Jpn J Cancer Res. 89 (9): 879–82. doi:10.1111/j.1349-7006.1998.tb00643.x. PMC 5921953. PMID 9818021.
^ "Entrez Gene: UPK3A uroplakin 3A".
^ Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT (2009). "Uroplakins in urothelial biology, function, and disease". Kidney Int. 75 (11): 1153–65. doi:10.1038/ki.2009.73. PMC 3717210. PMID 19340092.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100373 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9818021-5] Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y (Dec 1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma". Jpn J Cancer Res. 89 (9): 879–82. doi:10.1111/j.1349-7006.1998.tb00643.x. PMC 5921953. PMID 9818021.

[entrez-6] "Entrez Gene: UPK3A uroplakin 3A".

[7] Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT (2009). "Uroplakins in urothelial biology, function, and disease". Kidney Int. 75 (11): 1153–65. doi:10.1038/ki.2009.73. PMC 3717210. PMID 19340092.

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