Urotensin-II

UTS2
Identifiers
AliasesUTS2, PRO1068, U-II, UCN2, UII, urotensin 2
External IDsOMIM: 604097; MGI: 1346329; HomoloGene: 4939; GeneCards: UTS2; OMA:UTS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10911

24111

Ensembl

ENSG00000049247

ENSMUSG00000028963

UniProt

O95399

Q9QZQ3

RefSeq (mRNA)

NM_006786
NM_021995

NM_011910

RefSeq (protein)

NP_006777
NP_068835

NP_036040

Location (UCSC)Chr 1: 7.84 – 7.85 MbChr 4: 151.08 – 151.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Urotensin-II
Names
IUPAC name
L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine (5→10)-disulfide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1
    Key: HFNHAPQMXICKCF-USJMABIRSA-N
  • InChI=1/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1
    Key: HFNHAPQMXICKCF-USJMABIRBM
  • C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)Cc3ccccc3)Cc4c[nH]c5c4cccc5)CCCCN)Cc6ccc(cc6)O)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O
Properties
C64H85N13O18S2
Molar mass 1388.6 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Urotensin-II (U-II) is a peptide ligand that is the strongest known vasoconstrictor.[5] Because of the involvement of the UII system in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal,[6][7][8] it represents a promising target for the development of new drugs.[9]

In humans, Urotensin-2 is encoded by the UTS2 gene.[10][11][12]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000049247 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028963 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Clozel M, Binkert C, Birker-Robaczewska M, Boukhadra C, Ding SS, Fischli W, Hess P, Mathys B, Morrison K, Müller C, Müller C, Nayler O, Qiu C, Rey M, Scherz MW, Velker J, Weller T, Xi JF, Ziltener P (Oct 2004). "Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System". (primary). The Journal of Pharmacology and Experimental Therapeutics. 311 (1): 204–12. doi:10.1124/jpet.104.068320. PMID 15146030. S2CID 2011410.
  6. ^ Douglas SA, Dhanak D, Johns DG (Feb 2004). "From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function". (review). Trends in Pharmacological Sciences. 25 (2): 76–85. doi:10.1016/j.tips.2003.12.005. PMID 15102493.
  7. ^ Vaudry H, Do Rego JC, Le Mevel JC, Chatenet D, Tostivint H, Fournier A, Tonon MC, Pelletier G, Conlon JM, Leprince J (2010). "Urotensin II, from fish to human". (review). Annals of the New York Academy of Sciences. 1200 (1): 53–66. Bibcode:2010NYASA1200...53V. doi:10.1111/j.1749-6632.2010.05514.x. PMID 20633133. S2CID 25173513.
  8. ^ Vaudry H, Leprince J, Chatenet D, Fournier A, Lambert DG, Le Mével JC, Ohlstein EH, Schwertani A, Tostivint H, Vaudry D (2015). "International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function". (review). Pharmacological Reviews. 67 (1): 214–58. doi:10.1124/pr.114.009480. PMID 25535277.
  9. ^ Leprince J, Chatenet D, Dubessy C, Fournier A, Pfeiffer B, Scalbert E, Renard P, Pacaud P, Oulyadi H, Ségalas-Milazzo I, Guilhaudis L, Davoust D, Tonon MC, Vaudry H (May 2008). "Structure-activity relationships of urotensin II and URP". (review). Peptides. 29 (5): 658–73. doi:10.1016/j.peptides.2007.08.014. PMID 17931747. S2CID 23592090.
  10. ^ Coulouarn Y, Lihrmann I, Jegou S, Anouar Y, Tostivint H, Beauvillain JC, Conlon JM, Bern HA, Vaudry H (Dec 1998). "Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord". Proceedings of the National Academy of Sciences of the United States of America. 95 (26): 15803–8. Bibcode:1998PNAS...9515803C. doi:10.1073/pnas.95.26.15803. PMC 28125. PMID 9861051.
  11. ^ Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA (Sep 1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14". Nature. 401 (6750): 282–6. Bibcode:1999Natur.401..282A. doi:10.1038/45809. PMID 10499587. S2CID 4564765.
  12. ^ "Entrez Gene: UTS2 urotensin 2".