Urotensin-II receptor

UTS2R
Identifiers
Aliases	UTS2R, GPR14, UR-2-R, UTR, UTR2, urotensin 2 receptor
External IDs	OMIM: 600896; MGI: 2183450; HomoloGene: 10345; GeneCards: UTS2R; OMA:UTS2R - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,377,458 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	121,052,799 bp
RNA expression pattern
	Top expressed in
	right testis; ; apex of heart; ; left testis; ; right auricle; ; thigh; ; left lobe of thyroid gland; ; muscle of thigh; ; left ventricle; ; right lobe of thyroid gland; ; right frontal lobe;
	Top expressed in
	blastocyst; ; ankle; ; zygote; ; morula; ; secondary oocyte; ; embryo; ; embryo; ; primary oocyte; ; muscle of thigh; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; urotensin II receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; recycling endosome; membrane; plasma membrane; integral component of plasma membrane; early endosome;
Biological process	negative regulation of urine volume; negative regulation of blood pressure; positive regulation of fibroblast proliferation; positive regulation of cytosolic calcium ion concentration; blood circulation; positive regulation of angiogenesis; regulation of blood pressure; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of blood pressure; positive regulation of cell growth; positive regulation of vasoconstriction; positive regulation of circadian sleep/wake cycle, wakefulness; positive regulation of circadian sleep/wake cycle, REM sleep; negative regulation of renal sodium excretion; neuropeptide signaling pathway; negative regulation of glomerular filtration; signal transduction; blood vessel diameter maintenance; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2837
	217369
	ENSG00000181408
	ENSMUSG00000039321
	Q9UKP6
	Q8VIH9
	NM_018949; NM_001381897
	NM_145440
	NP_061822; NP_001368826
	NP_663415
	Wikidata
View/Edit Human	View/Edit Mouse

The urotensin-2 receptor (UR-II-R) also known as GPR14 is a class A rhodopsin family G protein coupled-receptor (GPCR) that is 386 amino acids long which binds primarily to the neuropeptide urotensin II.^[1] The receptor quickly rose to prominence when it was found that when activated by urotensin II it induced the most potent vasoconstriction effect ever seen.^[5] While the precise function of the urotensin II receptor is not fully known it has been linked to cardiovascular effects, stress, and REM sleep.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039321 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clozel M, Binkert C, Birker-Robaczewska M, Boukhadra C, Ding SS, Fischli W, Hess P, Mathys B, Morrison K, Müller C, Müller C, Nayler O, Qiu C, Rey M, Scherz MW, Velker J, Weller T, Xi JF, Ziltener P (Oct 2004). "Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System". The Journal of Pharmacology and Experimental Therapeutics. 311 (1): 204–12. doi:10.1124/jpet.104.068320. PMID 15146030. S2CID 2011410.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181408 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039321 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Clozel M, Binkert C, Birker-Robaczewska M, Boukhadra C, Ding SS, Fischli W, Hess P, Mathys B, Morrison K, Müller C, Müller C, Nayler O, Qiu C, Rey M, Scherz MW, Velker J, Weller T, Xi JF, Ziltener P (Oct 2004). "Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System". The Journal of Pharmacology and Experimental Therapeutics. 311 (1): 204–12. doi:10.1124/jpet.104.068320. PMID 15146030. S2CID 2011410.

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