User:MichaHalle/Protein cross-linking

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Protein cross-linking is a biochemical method to probe structures of proteins or detrmine interaction sites between proteins. Proteins can for example be cross linked to their substrates, in the case of enzymes, or to binding partners, like nucleic acids or small molecules. Cross-linking can also occur between two proteins or even intramolecular. Cross links can be analysed for example by SDS-PAGE. The exact site of the cross link can be determined using mass spectrometry. ^[1]. This information can be used to probe the 3-dimensional structure, as identified cross links can be used as a molecular ruler giving constraints for protein structure modeling.