VE-cadherin

CDH5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KOH
Identifiers
Aliases	CDH5, 7B4, CD144, VE-cadherin, cadherin 5
External IDs	OMIM: 601120; MGI: 105057; HomoloGene: 1359; GeneCards: CDH5; OMA:CDH5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 66,366,622 bp[1] End 66,404,784 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.04 cM Start 104,828,257 bp[2] End 104,871,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung apex of heart lower lobe of lung subcutaneous adipose tissue placenta pericardium vena cava left ventricle right lobe of thyroid gland Top expressed in gastrula cardiac muscle tissue of left ventricle decidua left lung interventricular septum left lung lobe lactiferous gland right lung right lung lobe extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding beta-catenin binding transmembrane transporter binding metal ion binding protein binding protein phosphatase binding signaling receptor binding cytoskeletal protein binding protein homodimerization activity cadherin binding vascular endothelial growth factor receptor 2 binding Cellular component integral component of membrane membrane cell-cell junction bicellular tight junction adherens junction cell surface cell junction external side of plasma membrane cell periphery plasma membrane catenin complex Biological process positive regulation of establishment of endothelial barrier cell adhesion cell-cell junction assembly adherens junction organization transforming growth factor beta receptor signaling pathway regulation of establishment of cell polarity negative regulation of cell population proliferation homophilic cell adhesion via plasma membrane adhesion molecules blood vessel maturation cell-cell adhesion negative regulation of inflammatory response positive regulation of angiogenesis calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1003 12562 Ensembl ENSG00000179776 ENSMUSG00000031871 UniProt P33151 P55284 RefSeq (mRNA) NM_001114117 NM_001795 NM_009868 RefSeq (protein) NP_001786 NP_033998 Location (UCSC) Chr 16: 66.37 – 66.4 Mb Chr 8: 104.83 – 104.87 Mb PubMed search [3] [4]
Wikidata
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Cadherin-5, or VE-cadherin (vascular endothelial cadherin), also known as CD144 (Cluster of Differentiation 144), is a type of cadherin. It is encoded by the human gene CDH5.^[5]