VEZT

VEZT
Identifiers
Aliases	VEZT, VEZATIN, vezatin, adherens junctions transmembrane protein
External IDs	MGI: 2143698; HomoloGene: 9739; GeneCards: VEZT; OMA:VEZT - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse)[1] Band 10|10 C2 Start 93,775,027 bp[1] End 93,871,679 bp[1]
Gene ontology Molecular function myosin binding Cellular component integral component of membrane adherens junction cell junction plasma membrane acrosomal vesicle membrane cytoplasmic vesicle nucleus nucleoplasm cytosol stereocilia ankle link complex cell projection stereocilium membrane Biological process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55591 215008 Ensembl ENSG00000028203 ENSMUSG00000036099 UniProt Q9HBM0 Q3ZK22 RefSeq (mRNA) NM_017599 NM_172538 NM_001304572 NM_001304575 NM_001304720 RefSeq (protein) NP_060069 NP_001339017 NP_001339018 NP_001339019 NP_001339020 NP_001339021 NP_001339022 NP_001339023 NP_001339024 NP_001339025 NP_001339026 NP_001339027 NP_001339028 NP_001339029 NP_001339030 NP_001339031 NP_001339032 NP_001339033 NP_001339034 NP_001339035 NP_001339036 NP_001339037 NP_001339038 NP_001339039 NP_001339040 NP_001339041 NP_001339042 NP_001339043 NP_001339044 NP_001339045 NP_001339046 NP_001339047 NP_001339048 NP_001291501 NP_001291504 NP_001291649 NP_766126 Location (UCSC) n/a Chr 10: 93.78 – 93.87 Mb PubMed search [2] [3]
Wikidata
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VEZT is a gene located on chromosome 12 and encodes for the protein vezatin. Vezatin is a major component of the cadherin-catenin complex that is critical to the formation and maintenance of adherens junctions.^[4] The protein is expressed in most epithelial cells and is crucial to the formation of cell-cell contact junctions. Mutations of the gene can lead to upregulation or downregulation of the protein which can have detrimental effects on physiological systems, particularly those involved in development.