VP40

VP40
VP40 matrix protein hexamer, Ebola virus
Identifiers
Symbol	VP40
Pfam	PF07447
InterPro	IPR008986
SCOP2	1h2c / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, VP40 is the name of a viral matrix protein. Most commonly, it is found in the Ebola virus (EBOV),^[1] a type of non-segmented, negative-strand RNA virus. Ebola virus causes a severe and often fatal haemorrhagic fever in humans, known as Ebola virus disease. The virus matrix protein VP40 is a major structural protein that plays a central role in virus assembly and budding at the plasma membrane of infected cells. VP40 proteins work by associating with cellular membranes, interacting with the cytoplasmic tails of glycoproteins and binding to the ribonucleoprotein complex.^{[citation needed]}