VWA2

VWA2
Identifiers
Aliases	VWA2, AMACO, CCSP-2, NET42, von Willebrand factor A domain containing 2, CCSP2
External IDs	OMIM: 618281; MGI: 2684334; HomoloGene: 18238; GeneCards: VWA2; OMA:VWA2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	114,294,489 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	56,900,510 bp
RNA expression pattern
	Top expressed in
	thymus; ; right uterine tube; ; olfactory zone of nasal mucosa; ; sural nerve; ; testicle; ; body of stomach; ; fundus; ; skin of abdomen; ; body of pancreas; ; skin of leg;
	Top expressed in
	otic vesicle; ; molar; ; secondary oocyte; ; primary oocyte; ; lip; ; tail of embryo; ; proximal tubule; ; genital tubercle; ; cervix; ; pulmonary alveolar epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; calcium ion binding;
Cellular component	extracellular region; basement membrane; extracellular exosome; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	calcium-independent cell-matrix adhesion; protein homooligomerization; regulation of insulin receptor signaling pathway; growth plate cartilage chondrocyte morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	340706
	240675
	ENSG00000165816
	ENSMUSG00000025082
	Q5GFL6
	Q70UZ7
	NM_001272046; NM_198496; NM_001320804
	NM_172840
	NP_001258975; NP_001307733
	NP_766428
	Wikidata
View/Edit Human	View/Edit Mouse

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.^[5]^[6]

AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.^[6] AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.^[7]

AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction,^[8] the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers;^[9] indicating that it might be a good candidate as a biomarker for this type of cancer.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165816 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025082 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: von Willebrand factor A domain containing 2".
^ ^a ^b Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". The Journal of Biological Chemistry. 278 (50): 50240–9. doi:10.1074/jbc.M307794200. PMID 14506275.
^ Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (October 2009). "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biology. 28 (8): 456–62. doi:10.1016/j.matbio.2009.07.006. PMID 19651211.
^ Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (May 2014). "AMACO is a component of the basement membrane-associated Fraser complex". The Journal of Investigative Dermatology. 134 (5): 1313–1322. doi:10.1038/jid.2013.492. PMC 4361737. PMID 24232570.
^ Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene. 24 (4): 724–31. doi:10.1038/sj.onc.1208134. PMID 15580307.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165816 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025082 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_340706-5] "Entrez Gene: von Willebrand factor A domain containing 2".

[pmid14506275-6] Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". The Journal of Biological Chemistry. 278 (50): 50240–9. doi:10.1074/jbc.M307794200. PMID 14506275.

[pmid19651211-7] Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (October 2009). "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biology. 28 (8): 456–62. doi:10.1016/j.matbio.2009.07.006. PMID 19651211.

[8] Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (May 2014). "AMACO is a component of the basement membrane-associated Fraser complex". The Journal of Investigative Dermatology. 134 (5): 1313–1322. doi:10.1038/jid.2013.492. PMC 4361737. PMID 24232570.

[pmid15580307-9] Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene. 24 (4): 724–31. doi:10.1038/sj.onc.1208134. PMID 15580307.

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