Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens.[1] It will not protect against osteoporosis.[2] With perhaps the exception of the Femring,[3] it also will not alleviate the hot flashes and hormonal imbalance caused by menopause.[2]