| Van Leusen reaction | |||||||||
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| Named after | Daan Van Leusen Albert M. Van Leusen | ||||||||
| Reaction type | Substitution reaction | ||||||||
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| Organic Chemistry Portal | van-leusen-reaction | ||||||||
The Van Leusen reaction is the reaction of a ketone with TosMIC leading to the formation of a nitrile. It was first described in 1977 by Van Leusen and co-workers.[1] When aldehydes are employed, the Van Leusen reaction is particularly useful to form oxazoles and imidazoles.
- ^ Van Leusen, Daan; Oldenziel, Otto; Van Leusen, Albert (1977). "Chemistry of sulfonylmethyl isocyanides. 13. A general one-step synthesis of nitriles from ketones using tosylmethyl isocyanide. Introduction of a one-carbon unit". J. Org. Chem. 42 (19). American Chemical Society: 3114–3118. doi:10.1021/jo00439a002.