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Vasilissis Sofias Avenue (Greek: Λεωφόρος Βασιλίσσης Σοφίας) is a major avenue in the east side of the center of Athens, the Greek capital. The avenue was originally part of the Kifisias Avenue. The part from Syntagma Square to the intersection with Alexandras Avenue was renamed after Queen Sophia, the consort of King Constantine I. The avenue begins at the intersections of Amalias Avenue and Panepistimiou Street and ends by Alexandras, Kifissias and Mesogeion Avenues as well as Feidippou Street, with a total length of approximately 3 km. A section of the avenue is part of the old GR-1, and a branch of GR-54.
As many historical buildings and landmarks are located on the avenue, such as the Old Royal Palace (today housing the Greek Parliament) and the National Gardens of Athens, the mansions of very important Greeks and foreigners (today most of them housing embassies and museums) (e.g. the residence of the Greek Prime Minister Eleutherios Venizelos-now part of the British embassy, the mansion of Sophie de Marbois-Lebrun, Duchess of Plaisance-now the Byzantine and Christian Museum, the mansion of business magnate and tycoon Othon Stathatos-today part of the Goulandris Museum of Cycladic Art), Vasilissis Sofias Avenue is one of the most chic and prestigious streets in the Greek capital. Because of the very high price of land on this street, most of the buildings seen on Vasilissis Sofias Avenue were mainly built in the 1950s–1960s, but others built in the beginnings of the 20th century are also commonly seen. Except from residences, medical doctors' private practices, banks, museums, embassies and high-end hotels are common on this historical street.
The westbound lanes turn into Amalias Avenue and Panepistimiou Street, and the northbound of Amalias turns into Vasileias Sofias Avenue and Panepistimiou Street ; there is no traffic flow from the eastbound of Panepistimiou Street as it forms a one-way route westbound, and since the 2000s transit traffic has been excluded. Three Athens Metro stations (Line 3) are on, or near, Vassilissis Sofias Avenue: Syntagma, Evangelismos, Megaro Moussikis (the Evangelismos station is on the avenue).