Vasopressin receptor 1B

AVPR1B
Identifiers
Aliases	AVPR1B, AVPR3, arginine vasopressin receptor 1B, V1bR, VPR3, vasopressin 3 receptor, antidiuretic hormone receptor 1B
External IDs	OMIM: 600264; MGI: 1347010; HomoloGene: 22678; GeneCards: AVPR1B; OMA:AVPR1B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,117,699 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,539,738 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; endothelial cell; ; secondary oocyte; ; islet of Langerhans; ; gonad; ; visceral pleura; ; duodenum; ; metanephros; ; embryo; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; embryo; ; blastocyst; ; embryo; ; meninges; ; spinal cord; ; hippocampus proper; ; vasculature; ; thalamus; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide binding; G protein-coupled receptor activity; signal transducer activity; protein kinase C binding; vasopressin receptor activity;
Cellular component	integral component of membrane; endosome; plasma membrane; integral component of plasma membrane; membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; regulation of systemic arterial blood pressure by vasopressin; cellular response to hormone stimulus; activation of phospholipase C activity; positive regulation of vasoconstriction; signal transduction; response to peptide;
	Sources:Amigo / QuickGO
Orthologs
	553
	26361
	ENSG00000198049
	ENSMUSG00000026432
	P47901
	Q9WU02
	NM_000707
	NM_011924
	NP_000698
	NP_036054
	Wikidata
View/Edit Human	View/Edit Mouse

Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene.

V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G protein-coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. It is a major contributor to homeostasis and the control of water, glucose, and salts in the blood. Arginine vasopressin has four receptors, each of which are located in different tissues and have specific functions. AVPR1b is a G protein-coupled pituitary receptor that has only recently been characterized because of its rarity.^[5]

It has been found that the 420-amino-acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A, AVP2 and oxytocin receptors.^[6] AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin/oxytocin family subfamily.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198049 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026432 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Holmes CL, Landry DW, Granton JT (December 2003). "Science review: Vasopressin and the cardiovascular system part 1--receptor physiology". Critical Care. 7 (6): 427–34. doi:10.1186/cc2337. PMC 374366. PMID 14624682.
^ van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S (March 2004). "A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression". Molecular Psychiatry. 9 (3): 287–92. doi:10.1038/sj.mp.4001420. PMID 15094789. S2CID 25408207.
^ "anti-Arginine Vasopressin Receptor 1B (AVPR1B) antibody (ABIN122463)". antibodies-online.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198049 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026432 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14624682-5] Holmes CL, Landry DW, Granton JT (December 2003). "Science review: Vasopressin and the cardiovascular system part 1--receptor physiology". Critical Care. 7 (6): 427–34. doi:10.1186/cc2337. PMC 374366. PMID 14624682.

[pmid15094789-6] van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S (March 2004). "A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression". Molecular Psychiatry. 9 (3): 287–92. doi:10.1038/sj.mp.4001420. PMID 15094789. S2CID 25408207.

[urlanti-Arginine_Vasopressin_Receptor_1B_(AVPR1B)_antibody_(ABIN122463)-7] "anti-Arginine Vasopressin Receptor 1B (AVPR1B) antibody (ABIN122463)". antibodies-online.

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