Ventrolateral prefrontal cortex

The ventrolateral prefrontal cortex (VLPFC) is a section of the prefrontal cortex located on the inferior frontal gyrus, bounded superiorly by the inferior frontal sulcus and inferiorly by the lateral sulcus. It is attributed to the anatomical structures of Brodmann's area (BA) 47, 45 and 44 (considered the subregions of the VLPFC – the anterior, mid and posterior subregions).

Specific functional distinctions have been presented between the three Brodmann subregions of the VLPFC.^[1][2][3] There are also specific functional differences in activity in the right and left VLPFC.^[4] Neuroimaging studies employing various cognitive tasks have shown that the right VLPFC region is a critical substrate of control.^[4] At present, two prominent theories feature the right VLPFC as a key functional region. From one perspective, the right VLPFC is thought to play a critical role in motor inhibition, where control is engaged to stop or override motor responses.^[5] Alternatively, Corbetta and Shulman^[2][6][7] have advanced the hypothesis that there are two distinct frontoparietal networks involved in spatial attention, with the right VLPFC being a component of a right-lateralized ventral attention network that governs reflexive reorienting. From this perspective, the right lateral PFC, along with a region spanning the right temporoparietal junction (TPJ) and the inferior parietal lobule, are engaged when abrupt onsets occur in the environment, suggesting that these regions are involved in re-orienting attention to perceptual events that occur outside the current focus of attention.^[4] Also, the VLPFC is the end point of the ventral pathway (stream) that brings information about the stimuli's characteristics.^[8]