Versican

VCAN
Identifiers
Aliases	VCAN, CSPG2, ERVR, GHAP, PG-M, WGN, WGN1, versican
External IDs	OMIM: 118661; MGI: 102889; HomoloGene: 3228; GeneCards: VCAN; OMA:VCAN - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.2-q14.3 Start 83,471,618 bp[1] End 83,582,303 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 C3|13 45.5 cM Start 89,803,431 bp[2] End 89,890,628 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte pericardium right coronary artery ventricular zone synovial joint tendon of biceps brachii saphenous vein Descending thoracic aorta trabecular bone ascending aorta Top expressed in genital tubercle vas deferens tail of embryo cumulus cell semi-lunar valve efferent ductule maxillary prominence hand dermis molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding glycosaminoglycan binding protein binding carbohydrate binding extracellular matrix structural constituent hyaluronic acid binding extracellular matrix structural constituent conferring compression resistance Cellular component membrane extracellular matrix lysosomal lumen Golgi lumen extracellular space endoplasmic reticulum lumen extracellular region collagen-containing extracellular matrix intracellular membrane-bounded organelle Biological process glycosaminoglycan metabolic process skeletal system development cell recognition chondroitin sulfate biosynthetic process extracellular matrix organization multicellular organism development central nervous system development cell adhesion osteoblast differentiation chondroitin sulfate catabolic process dermatan sulfate biosynthetic process glial cell migration post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1462 13003 Ensembl ENSG00000038427 ENSMUSG00000021614 UniProt P13611 Q86W61 Q62059 RefSeq (mRNA) NM_004385 NM_001126336 NM_001164097 NM_001164098 NM_001081249 NM_001134474 NM_001134475 NM_019389 NM_172955 RefSeq (protein) NP_001119808 NP_001157569 NP_001157570 NP_004376 NP_001119808.1 n/a Location (UCSC) Chr 5: 83.47 – 83.58 Mb Chr 13: 89.8 – 89.89 Mb PubMed search [3] [4]
Wikidata
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Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.^[5][6]

Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan.^[7] They designated it versican in recognition of its versatile modular structure.

Versican belongs to the lectican protein family, with aggrecan (abundant in cartilage), brevican and neurocan (nervous system proteoglycans) as other members. Versican is also known as chondroitin sulfate proteoglycan core protein 2 or chondroitin sulfate proteoglycan 2 (CSPG2), and PG-M.