Vitamin D-binding protein

GC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGC, DBP, DBP/GRD3, HEL-S-51, VDBG, VDBP, Gc-MAF, GcMAF, vitamin D binding protein, DBP-maf, VDB, GC vitamin D binding protein
External IDsOMIM: 139200; MGI: 95669; HomoloGene: 486; GeneCards: GC; OMA:GC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000583
NM_001204306
NM_001204307

NM_008096

RefSeq (protein)

NP_000574
NP_001191235
NP_001191236

NP_032122

Location (UCSC)Chr 4: 71.74 – 71.8 MbChr 5: 89.57 – 89.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene.[5][6] DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145321Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035540Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mikkelsen M, Jacobsen P, Henningsen K (Jul 1977). "Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System". Human Heredity. 27 (2): 105–7. doi:10.1159/000152857. PMID 558959.
  6. ^ "Entrez Gene: GC group-specific component (vitamin D binding protein)".
  7. ^ Bouillon, R.; Schuit, F.; Antonio, L.; Rastinejad, F. (2020). "Vitamin D Binding Protein: A Historic Overview". Frontiers in Endocrinology. 10: 910. doi:10.3389/fendo.2019.00910. PMC 6965021. PMID 31998239.