WTAP (gene)

WTAP
Identifiers
Aliases	WTAP, Mum2, Wilms tumor 1 associated protein, WT1 associated protein
External IDs	OMIM: 605442; MGI: 1926395; HomoloGene: 68422; GeneCards: WTAP; OMA:WTAP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	159,756,319 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	13,213,056 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; epithelium of nasopharynx; ; vena cava; ; buccal mucosa cell; ; cartilage tissue; ; amniotic fluid; ; germinal epithelium; ; pericardium; ; parietal pleura; ; caput epididymis;
	Top expressed in
	morula; ; ciliary body; ; medullary collecting duct; ; vestibular membrane of cochlear duct; ; retinal pigment epithelium; ; endothelial cell of lymphatic vessel; ; condyle; ; primary oocyte; ; fossa; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nuclear membrane; nucleus; RNA N6-methyladenosine methyltransferase complex; nuclear speck; nucleoplasm; cytoplasm;
Biological process	RNA splicing; cell cycle; mRNA processing; mRNA methylation; regulation of alternative mRNA splicing, via spliceosome; multicellular organism development; RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9589
	60532
	ENSG00000146457
	ENSMUSG00000060475
	Q15007
	Q9ER69
NM_001270531; NM_001270532; NM_001270533; NM_004906; NM_152857;
	NM_152858
	NM_001113532; NM_001113533; NM_175394; NM_001379058
NP_001257460; NP_001257461; NP_001257462; NP_004897; NP_690596;
	NP_690597
	NP_001107004; NP_001107005; NP_780603; NP_001365987
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.^[5]^[6]^[7]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060475 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
^ Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet. 9 (15): 2231–9. doi:10.1093/oxfordjournals.hmg.a018914. PMID 11001926.
^ ^a ^b "Entrez Gene: WTAP Wilms tumor 1 associated protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060475 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7788527-5] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[pmid11001926-6] Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet. 9 (15): 2231–9. doi:10.1093/oxfordjournals.hmg.a018914. PMID 11001926.

[entrez-7] "Entrez Gene: WTAP Wilms tumor 1 associated protein".

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