| | | | | | | | Thomas Walpole (died 1514) |
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| | | | | | | | Edward Walpole (died 1559) | | Henry Walpole |
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| | | | | | | | John Walpole (died 1588) | | John Walpole (died 1557) | | Christopher Walpole |
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| | | | Edward Walpole (1560–1637) | | Calybut Walpole (1561–1646) | | | | | | Henry Walpole (1558–1595) |
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| | | | | | | | Robert Walpole (1593–1663) |
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| | | | | | | | Sir Edward Walpole (1621–1668) |
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| | | | | | | | Robert Walpole (1650–1700) | | Horatio Walpole (1663–1717) |
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Catherine Shorter (died 1737) | | Robert Walpole, 1st Earl of Orford (1676–1745) | | Maria Skerrett (died 1738) | | Horatio Walpole, 1st Baron Walpole (1678–1757) | | Galfridus Walpole (1683–1726) | | Dorothy Walpole (1686–1726) |
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Robert Walpole, 2nd Earl of Orford (1709–1751) | | Sir Edward Walpole (1706–1784) | | Horatio Walpole, 4th Earl of Orford (1717–1797) | | Horatio Walpole, 1st Earl of Orford (1723–1809) | | Thomas Walpole (1727–1803) | | Richard Walpole (1728–1798) | | | | | | Robert Walpole (1736–1810) |
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George Walpole, 3rd Earl of Orford (1730–1791) | | Maria Walpole (1736–1807) | | Horatio Walpole, 2nd Earl of Orford (1752–1822) | | George Walpole (1758–1835) | | Thomas Walpole (1755–1840) | | | | | | | | | | Robert Walpole (1781–1856) |
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| | | | | | | | Horatio Walpole, 3rd Earl of Orford (1783–1858) | | John Walpole (1787–1859) | | Thomas Walpole (1805–1881) | | Spencer Horatio Walpole (1808–1898) | | Sir Robert Walpole (1808–1876) | | Robert Seymour Walpole (1820–1910) | |
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| | | | Horatio Walpole, 4th Earl of Orford (1813–1894) | | Frederick Walpole (1822–1876) | | Lady Dorothy Walpole (1826–1913) | | Henry Spencer Vade-Walpole (1837–1913) | | Sir Spencer Walpole (1839–1907) | | | | | | Somerset Walpole (1854–1929) |
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| | | | | | | | Robert Walpole, 5th Earl of Orford (1854–1931) | | | | | | Horatio Spencer Walpole (1881–1918) | | | | | | | | | | Sir Hugh Walpole (1884–1941) |
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| | | | | | | | | | | | | | | | Robert Henry Montgomerie Walpole, 9th Baron Walpole (1913–1989) |
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| | | | | | | | | | | | | | | | Robert Walpole, 10th Baron Walpole (1938–2021) | | Judith Schofield (1939–1993) |
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| | | | | | | | | | | | | | | | Alice Walpole (born 1963) | | Jonathan Walpole, 11th Baron Walpole (born 1967) |