White sponge nevus

White sponge nevus
Other namesWhite sponge naevus, Cannon's disease, Hereditary leukokeratosis of mucosa, White sponge nevus of Cannon, Familial white folded dysplasia,[1][2] or Oral epithelial nevus[3]
White sponge nevus has an autosomal dominant pattern of inheritance.
SpecialtyOral medicine Edit this on Wikidata

White sponge nevus (WSN) is an autosomal dominant[4] condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by one or more mutations in genes coding for keratin, which causes a defect in the normal process of keratinization of the mucosa. This results in lesions which are thick, white and velvety on the inside of the cheeks within the mouth. Usually, these lesions are present from birth or develop during childhood. The condition is benign and usually requires no treatment. WSN can, however, predispose affected individuals to over-growth/imbalance of the oral microbiota, which may require antibiotic and/or antifungal treatment.

  1. ^ Online Mendelian Inheritance in Man (OMIM): 193900
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 709, 734, 738, 740. ISBN 978-1-4160-2999-1.
  3. ^ Soames, JV; Southam, J.C. (1999). Oral pathology (3rd ed.). Oxford [u.a.]: Oxford Univ. Press. pp. 141. ISBN 978-0192628947.
  4. ^ Cite error: The named reference pmid11379896 was invoked but never defined (see the help page).