Conditioned Place Preference (CPP) is a form of Pavlovian conditioning used to measure the motivational effects of objects or experiences.[1] This paradigm can also be used to measure conditioned place aversion with an identical procedure involving aversive stimuli instead. Both procedures usually involve mice or rats as subjects.[2][3] This procedure can be used to measure extinction and reinstatement of the conditioned stimulus. Certain drugs are used in this paradigm to measure their reinforcing properties. Two different methods are used to choose the compartments to be conditioned, and these are biased vs. unbiased. The biased method allows the animal to explore the apparatus, and the compartment they least prefer is the one that the drug is administered in and the one they most prefer is the one where the vehicle is injected.[4] This method allows the animal to choose the compartment they get the drug and vehicle in. In comparison, the unbiased method doesn't allow the animal to choose what compartment they get the drug and vehicle in and instead the researcher chooses the compartments.[5]
- ^ Cite error: The named reference
Tzschentke2007was invoked but never defined (see the help page). - ^ Campbell J., Wood R., Spear L. (2000) Cocaine and morphine-induced place conditioning in adolescent and adult rats. Physiol Behav 68:487–493
- ^ Adriani W., Laviola G. (2002) Spontaneous novelty seeking and amphetamine-induced conditioning and sensitization in adult mice: evidence of dissociation as a function of age at weaning. Neuropsychopharmacology 27:225–236.
- ^ Prus, AJ., James, JR., Rosecrans, AJ.(2009). Methods of Behavioral Analysis in Neuroscience. Augusta, CRC press.
- ^ Prus, AJ., James, JR., Rosecrans, AJ.(2009). Methods of Behavioral Analysis in Neuroscience. Augusta, CRC press.