William B. Henderson was an African American farmer, and Republican state legislator in North Carolina.[1] He lived in Middleburg, North Carolina.
In 1892 he was elected to the North Carolina House of Representatives, but John P. Leach and the Democrats unseated him and several other Republicans.[2] He represented Vance County in the North Carolina Senate in 1897.[2][3]
In 1898, North Carolina Governor D. L. Russell appointed him as fertilizer inspector.[2]