William Mathews

William Mathews may refer to:

• William Mathews (cricketer) (1793–1858), English cricketer
• William A. Mathews (1800–1856), Texas colonist, soldier, courier and quartermaster in the Texas Revolution
• William Mathews (mountaineer) (1828–1901), English mountaineer and botanist
• William Gordon Mathews (1877–1923), federal judge and lawyer in West Virginia
• William Shirley Mathews (1848–1915, Osage Nation politician
• Bill Mathews (William Henry Mathews, 1919–2003), Canadian geologist