William McLean may refer to:
- Bill McLean (1918–1996), Australian soldier and rugby player
- William B. McLean (1914–1976), U.S. Navy physicist and ordnance expert
- William Campbell McLean (1854–1944), justice of the Supreme Court of Mississippi
- USNS William McLean, a 2011 U.S. Navy ship named for the physicist
- William McLean (civil servant) (1877–1967), Scottish Unionist Party MP for Glasgow Tradeston
- William McLean (bobsleigh) (1918–1963), British bobsledder who competed at the 1948 Winter Olympics in St. Moritz
- William McLean (Ohio politician) (1794–1839), U.S. Representative from Ohio
- William P. McLean (1836–1925), U.S. Representative from Texas
- William McLean (New Zealand politician) (1845–1914), New Zealand politician
- Billy McLean (umpire) (1835–1927), English professional baseball umpire