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William Small (1734–1775) was a Scottish physician and a professor of natural philosophy at the College of William and Mary in Williamsburg, Virginia. There he became an influential mentor of Thomas Jefferson, who went on to be a leading proponent of the American Revolution, principal author of the Declaration of Independence, and the third President of the United States. From 1765, Small was an influential medical doctor in Birmingham, England, where he was a member of the Lunar Society.