| Woodward cis-hydroxylation | |
|---|---|
| Named after | Robert Burns Woodward |
| Reaction type | addition reaction |
| Identifiers | |
| Organic Chemistry Portal | woodward-reaction |
The Woodward cis-hydroxylation (also known as the Woodward reaction) is the chemical reaction of alkenes with iodine and silver acetate in wet acetic acid to form cis-diols.[1][2](conversion of olefin into cis-diol)
The reaction is named after its discoverer, Robert Burns Woodward.
This reaction has found application in steroid synthesis.[3]
- ^ Woodward, R. B., U.S. patent 2,687,435
- ^ Woodward, R. B.; Brutcher, F. V. (1958). "cis-Hydroxylation of a Synthetic Steroid Intermediate with Iodine, Silver Acetate and Wet Acetic Acid". J. Am. Chem. Soc. 80 (1): 209–211. doi:10.1021/ja01534a053. ISSN 0002-7863.
- ^ Mangoni, L.; Dovinola, V. (1969). "The stereochemistry of woodward cis-hydroxylation in some steroidal olefins". Tetrahedron Letters. 10 (60): 5235–5238. doi:10.1016/S0040-4039(01)88931-0. ISSN 0040-4039.