XAF1

XAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LXW
Identifiers
Aliases	XAF1, BIRC4BP, HSXIAPAF1, XIAPAF1, XIAP associated factor 1
External IDs	OMIM: 606717; MGI: 3772572; HomoloGene: 49488; GeneCards: XAF1; OMA:XAF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	6,775,647 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,204,559 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right ovary; ; left ovary; ; gallbladder; ; right uterine tube; ; monocyte; ; right lobe of liver; ; visceral pleura; ; spleen; ; endothelial cell;
	Top expressed in
	decidua; ; cervix; ; right lung; ; epithelium of small intestine; ; right lung lobe; ; subcutaneous adipose tissue; ; carotid body; ; gastrula; ; sciatic nerve; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; zinc ion binding;
Cellular component	cytosol; cytoplasm; nucleus; mitochondrion;
Biological process	apoptotic process; type I interferon signaling pathway; response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
	54739
	327959
	ENSG00000132530
	ENSMUSG00000040483
	Q6GPH4
	Q5NBU8
NM_017523; NM_199139; NM_001353134; NM_001353135; NM_001353136;
	NM_001353137; NM_001353138; NM_001353139; NM_001353140
	NM_001037713; NM_001291153
NP_059993; NP_954590; NP_001340063; NP_001340064; NP_001340065;
	NP_001340066; NP_001340067; NP_001340068; NP_001340069
	NP_001032802; NP_001278082
	Wikidata
View/Edit Human	View/Edit Mouse

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132530 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096.
^ Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. S2CID 19731886.
^ "Entrez Gene: XAF1 XIAP associated factor-1".