X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.[4][5]
XIAP is a member of the inhibitor of apoptosis family of proteins (IAP). IAPs were initially identified in baculoviruses, but XIAP is one of the homologous proteins found in mammals.[6] It is so called because it was first discovered by a 273 base pair site on the X chromosome.[4] The protein is also called human IAP-like Protein (hILP), because it is not as well conserved as the human IAPS: hIAP-1 and hIAP-2.[4][7] XIAP is the most potent human IAP protein currently identified.[8]
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025860 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Cite error: The named reference
Listonwas invoked but never defined (see the help page). - ^ Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, Shiels H, Hardwick JM, Thompson CB (June 1996). "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors". The EMBO Journal. 15 (11): 2685–94. doi:10.1002/j.1460-2075.1996.tb00629.x. PMC 450204. PMID 8654366.
- ^ Holcik M, Korneluk RG (July 2000). "Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation". Molecular and Cellular Biology. 20 (13): 4648–57. doi:10.1128/MCB.20.13.4648-4657.2000. PMC 85872. PMID 10848591.
- ^ Cite error: The named reference
Duckettwas invoked but never defined (see the help page). - ^ Deveraux QL, Reed JC (February 1999). "IAP family proteins--suppressors of apoptosis". Genes & Development. 13 (3): 239–52. doi:10.1101/gad.13.3.239. PMID 9990849.