Xibornol

Xibornol
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01XX02 (WHO) ;
Identifiers
	IUPAC name 4,5-dimethyl-2-[(1S,4R,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl]phenol;
CAS Number	13741-18-9 ;
PubChem CID	11777299;
DrugBank	DB13714 ;
ChemSpider	9951982 ;
UNII	RQ12GMY0FZ;
KEGG	D07433 ;
ChEBI	CHEBI:131713 ;
ChEMBL	ChEMBL2104519;
CompTox Dashboard (EPA)	DTXSID60472406 ;
ECHA InfoCard	100.033.906
Chemical and physical data
Formula	C18H26O
Molar mass	258.405 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cc(c(cc1C2CC3CCC2(C)C3(C)C)C)C;
	InChI InChI=1S/C18H26O/c1-11-8-14(16(19)9-12(11)2)15-10-13-6-7-18(15,5)17(13,3)4/h8-9,13,15,19H,6-7,10H2,1-5H3 ; Key:RNRHMQWZFJXKLZ-UHFFFAOYSA-N ;
	(verify)

Xibornol is a lipophilic substance with antiseptic properties, mainly used in Italy and Spain. It is primarily administered to the throat as a spray mouthwash. As of 2007, all approved forms are water-based suspensions.^[1]

The drug was discovered in the 1970s.^[2]

^ Cirri M, Mura P, Mora PC (August 2007). "Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems". International Journal of Pharmaceutics. 340 (1–2): 84–91. doi:10.1016/j.ijpharm.2007.03.021. PMID 17531411.
^ Celandroni F, Mazzantini D, Calvigioni M, Ceccanti S, Vecchiani S, Battaglia S, et al. (2022). "Antimicrobial Activity of Xibornol and a Xibornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract". Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology. Vol. 1369. pp. 101–106. doi:10.1007/5584_2021_664. hdl:11568/1115592. ISBN 978-3-031-01994-4. PMID 34387849. S2CID 236998271.

[pmid17531411-1] Cirri M, Mura P, Mora PC (August 2007). "Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems". International Journal of Pharmaceutics. 340 (1–2): 84–91. doi:10.1016/j.ijpharm.2007.03.021. PMID 17531411.

[2] Celandroni F, Mazzantini D, Calvigioni M, Ceccanti S, Vecchiani S, Battaglia S, et al. (2022). "Antimicrobial Activity of Xibornol and a Xibornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract". Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology. Vol. 1369. pp. 101–106. doi:10.1007/5584_2021_664. hdl:11568/1115592. ISBN 978-3-031-01994-4. PMID 34387849. S2CID 236998271.

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