Xq28

The human X chromosome with Xq28 (green) located at the tip of the long arm of the chromosome. Studies of the X chromosome as well as the entire human genome have linked Xq28 to the heredity of homosexuality in human males.

Xq28 is a chromosome band and genetic marker situated at the tip of the X chromosome which has been studied since at least 1980.[1] The band contains three distinct regions, totaling about 8 Mbp of genetic information.[2] The marker came to the public eye in 1993 when studies by Dean Hamer and others indicated a link between the Xq28 marker and male sexual orientation.[3]

  1. ^ Pai, GS; Sprenkle, JA; Do, TT; Mareni, CE; Migeon, BR (1980). "Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation". Proceedings of the National Academy of Sciences of the United States of America. 77 (5): 2810–3. Bibcode:1980PNAS...77.2810P. doi:10.1073/pnas.77.5.2810. PMC 349494. PMID 6930669.
  2. ^ De Sario, Albertina; Geigl, Eva-Maria; Palmieri, Giuseppe; d'Urso, Michele; Bernardi, Giorgio (1996). "A Compositional Map of Human Chromosome Band Xq28". Proceedings of the National Academy of Sciences of the United States of America. 93 (3): 1298–302. Bibcode:1996PNAS...93.1298D. doi:10.1073/pnas.93.3.1298. JSTOR 38791. PMC 40074. PMID 8577758.
  3. ^ Hamer, D.; Hu, S; Magnuson, V.; Hu, N; Pattatucci, A. (1993). "A linkage between DNA markers on the X chromosome and male sexual orientation". Science. 261 (5119): 321–7. Bibcode:1993Sci...261..321H. doi:10.1126/science.8332896. PMID 8332896.