In molecular biology, the protein domain YTH refers to a member of the YTH family that has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells .[ 1] epitranscriptome as reader proteins for m6A.[ 2]
This protein domain , the YTH-domain, is conserved across all eukaryotes and suggests that the conserved C-terminal region plays a critical role in relaying the cytosolic Ca-signals to the nucleus , thereby regulating gene expression .[ 3]
^ Harigaya Y, Tanaka H, Yamanaka S, Tanaka K, Watanabe Y, Tsutsumi C, Chikashige Y, Hiraoka Y, Yamashita A, Yamamoto M (July 2006). "Selective elimination of messenger RNA prevents an incidence of untimely meiosis". Nature . 442 (7098): 45–50. Bibcode :2006Natur.442...45H . doi :10.1038/nature04881 . PMID 16823445 . S2CID 4383571 . ^ Miller, Lucas G.; Demny, Madeline; Tamamis, Phanourios; Contreras, Lydia M. (2023). "Characterization of epitranscriptome reader proteins experimentally and in silico: Current knowledge and future perspectives beyond the YTH domain" . Computational and Structural Biotechnology Journal . 21 : 3541–3556. doi :10.1016/j.csbj.2023.06.018 . ISSN 2001-0370 . PMC 10371769 PMID 37501707 . ^ Ok SH, Jeong HJ, Bae JM, Shin JS, Luan S, Kim KN (September 2005). "Novel CIPK1-associated proteins in Arabidopsis contain an evolutionarily conserved C-terminal region that mediates nuclear localization" . Plant Physiol . 139 (1): 138–50. doi :10.1104/pp.105.065649 . PMC 1203364 PMID 16113215 .