ZBP1

ZBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4M, 2LNB, 3EYI, 4KA4
Identifiers
Aliases	ZBP1, C20orf183, DAI, DLM-1, DLM1, Z-DNA binding protein 1
External IDs	OMIM: 606750; MGI: 1927449; HomoloGene: 10972; GeneCards: ZBP1; OMA:ZBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,620,576 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,060,716 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; buccal mucosa cell; ; blood; ; spleen; ; monocyte; ; lymph node; ; bone marrow cells; ; appendix; ; rectum; ; gallbladder;
	Top expressed in
	mucous cell of stomach; ; jejunum; ; thymus; ; granulocyte; ; intestinal villus; ; duodenum; ; blood; ; subcutaneous adipose tissue; ; mesenteric lymph nodes; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded RNA adenosine deaminase activity; protein binding; left-handed Z-DNA binding; RNA binding; identical protein binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	positive regulation of type I interferon production; immune system process; innate immune response; regulation of type I interferon production; biological process; positive regulation of type I interferon-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	81030
	58203
	ENSG00000124256
	ENSMUSG00000027514
	Q9H171
	Q9QY24
	NM_001160417; NM_001160418; NM_001160419; NM_030776; NM_001323966
	NM_001139519; NM_021394
	NP_001153889; NP_001153890; NP_001153891; NP_001310895; NP_110403
	NP_001132991; NP_067369
	Wikidata
View/Edit Human	View/Edit Mouse

Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a protein that in humans is encoded by the ZBP1 gene.^[5]^[6]

ZBP1 is also an abbreviation for chicken or rat β-actin zipcode-binding protein 1, a homolog of the human insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1) and murine CRD-BP, the proteins involved in mRNA transport (RNA-binding proteins, RBPs).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027514 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (February 2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1". Nucleic Acids Research. 30 (4): 993–1000. doi:10.1093/nar/30.4.993. PMC 100341. PMID 11842111.
^ "Entrez Gene: ZBP1 Z-DNA binding protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124256 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027514 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11842111-5] Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (February 2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1". Nucleic Acids Research. 30 (4): 993–1000. doi:10.1093/nar/30.4.993. PMC 100341. PMID 11842111.

[entrez-6] "Entrez Gene: ZBP1 Z-DNA binding protein 1".

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