ZP2

ZP2
Identifiers
Aliases	ZP2, ZPA, Zp-2, zona pellucida glycoprotein 2, OOMD6
External IDs	OMIM: 182888; MGI: 99214; HomoloGene: 48194; GeneCards: ZP2; OMA:ZP2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	21,214,510 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	119,744,514 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; testicle; ; placenta; ; mucosa of large intestine; ; gallbladder; ; mucosa of transverse colon; ; duodenum; ; C1 segment;
	Top expressed in
	blastocyst; ; primary oocyte; ; zygote; ; secondary oocyte; ; embryo; ; morula; ; ovary; ; muscle of thigh; ; epiblast; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acrosin binding; coreceptor activity; identical protein binding; protein binding;
Cellular component	extracellular matrix; integral component of membrane; extracellular region; multivesicular body; plasma membrane; endoplasmic reticulum; membrane; collagen-containing extracellular matrix;
Biological process	regulation of acrosome reaction; prevention of polyspermy; binding of sperm to zona pellucida; single fertilization; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7783
	22787
	ENSG00000284588; ENSG00000103310
	ENSMUSG00000030911
	Q05996
	P20239
	NM_001290104; NM_003460; NM_001376231; NM_001376232; NM_001376233
	NM_011775; NM_001374631
	NP_003451; NP_001363160; NP_001363161; NP_001363162
	NP_035905; NP_001361560
	Wikidata
View/Edit Human	View/Edit Mouse

Zona pellucida sperm-binding protein 2 is a protein that in humans is encoded by the ZP2 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000103310 GRCh38: Ensembl release 89: ENSG00000284588, ENSG00000103310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liang LF, Dean J (Apr 1993). "Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes". Dev Biol. 156 (2): 399–408. doi:10.1006/dbio.1993.1087. PMID 8385033.
^ "Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)".

[refGRCh38Ensembl-1] ENSG00000103310 GRCh38: Ensembl release 89: ENSG00000284588, ENSG00000103310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8385033-5] Liang LF, Dean J (Apr 1993). "Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes". Dev Biol. 156 (2): 399–408. doi:10.1006/dbio.1993.1087. PMID 8385033.

[entrez-6] "Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)".

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