ZP3

ZP3
Identifiers
Aliases	ZP3, ZP3A, ZP3B, ZPC, Zp-3, zona pellucida glycoprotein 3 (sperm receptor), zona pellucida glycoprotein 3, OOMD3
External IDs	OMIM: 182889; MGI: 99215; HomoloGene: 5178; GeneCards: ZP3; OMA:ZP3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,442,071 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,017,478 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; apex of heart; ; mucosa of transverse colon; ; bone marrow cells; ; ventricular zone; ; muscle tissue; ; body of pancreas; ; right adrenal cortex; ; nucleus accumbens;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; egg cell; ; embryo; ; morula; ; morula; ; embryo; ; ovary; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	acrosin binding; protein binding; carbohydrate binding; identical protein binding; receptor ligand activity; extracellular matrix structural constituent; structural constituent of egg coat;
Cellular component	integral component of membrane; membrane; extracellular matrix; plasma membrane; extracellular region; extracellular space; intracellular anatomical structure; collagen-containing extracellular matrix;
Biological process	positive regulation of inflammatory response; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of antral ovarian follicle growth; positive regulation of interferon-gamma production; blastocyst formation; positive regulation of interleukin-4 production; oocyte development; positive regulation of type IV hypersensitivity; positive regulation of transcription, DNA-templated; humoral immune response mediated by circulating immunoglobulin; positive regulation of acrosome reaction; positive regulation of humoral immune response; positive regulation of T cell proliferation; binding of sperm to zona pellucida; negative regulation of binding of sperm to zona pellucida; positive regulation of ovarian follicle development; positive regulation of acrosomal vesicle exocytosis; negative regulation of transcription, DNA-templated; phosphatidylinositol-mediated signaling; single fertilization; egg coat formation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7784
	22788
	ENSG00000188372
	ENSMUSG00000004948
	P21754
	P10761
	NM_007155; NM_001110354
	NM_011776
	NP_001103824; NP_009086
	NP_035906
	Wikidata
View/Edit Human	View/Edit Mouse

Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) or the sperm receptor, is a ZP module-containing protein that in humans is encoded by the ZP3 gene.^[5] ZP3 is the glycoprotein in the zona pellucida most important for inducting the acrosome reaction of sperm cells at the beginning of fertilization.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188372 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004948 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: zona pellucida glycoprotein 3 (sperm receptor)".
^ Litscher, E. S.; Williams, Z.; Wassarman, P. M. (2009). "Zona pellucida glycoprotein ZP3 and fertilization in mammals". Molecular Reproduction and Development. 76 (10): 933–941. doi:10.1002/mrd.21046. PMID 19504560. S2CID 21186053.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188372 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004948 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: zona pellucida glycoprotein 3 (sperm receptor)".

[6] Litscher, E. S.; Williams, Z.; Wassarman, P. M. (2009). "Zona pellucida glycoprotein ZP3 and fertilization in mammals". Molecular Reproduction and Development. 76 (10): 933–941. doi:10.1002/mrd.21046. PMID 19504560. S2CID 21186053.

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