ZP4

ZP4
Identifiers
Aliases	ZP4, ZBP, ZP1, ZPB, Zp-4, zona pellucida glycoprotein 4, ZPB2, ZP1B
External IDs	OMIM: 613514; HomoloGene: 49661; GeneCards: ZP4; OMA:ZP4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	237,890,922 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; pancreatic ductal cell; ; tibialis anterior muscle; ; cartilage tissue; ; mucosa of ileum; ; deltoid muscle; ; skin of thigh; ; placenta; ; pharynx;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	acrosin binding; identical protein binding; protein binding;
Cellular component	plasma membrane; membrane; integral component of membrane; extracellular region;
Biological process	binding of sperm to zona pellucida; negative regulation of binding of sperm to zona pellucida; positive regulation of humoral immune response; positive regulation of T cell proliferation; positive regulation of acrosome reaction; acrosomal vesicle exocytosis; single fertilization;
	Sources:Amigo / QuickGO
Orthologs
	57829
	n/a
	ENSG00000116996
	n/a
	Q12836
	n/a
	NM_021186
	n/a
	NP_067009
	n/a
	Wikidata
View/Edit Human

Zona pellucida sperm-binding protein 4, ZP-4 or avilesine, named after its discoverer Manuel Avilés Sánchez^[3] is a protein that in humans is encoded by the ZP4 gene.^[4]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116996 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Avilés M, Moros C, García-Vázquez FA, Gimeno L, Torrecillas A, Aliaga C, Bernardo-Pisa MV, Ballesta J, Izquierdo-Rico MJ (April 2015). "Four glycoproteins are expressed in the cat zona pellucida". Theriogenology. 83 (7): 1162–73. doi:10.1016/j.theriogenology.2014.12.019. PMID 25623231.
^ Harris JD, Hibler DW, Fontenot GK, Hsu KT, Yurewicz EC, Sacco AG (Mar 1995). "Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families". DNA Sequence. 4 (6): 361–93. doi:10.3109/10425179409010186. PMID 7841460.
^ "Entrez Gene: ZP4 zona pellucida glycoprotein 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116996 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid25623231-3] Avilés M, Moros C, García-Vázquez FA, Gimeno L, Torrecillas A, Aliaga C, Bernardo-Pisa MV, Ballesta J, Izquierdo-Rico MJ (April 2015). "Four glycoproteins are expressed in the cat zona pellucida". Theriogenology. 83 (7): 1162–73. doi:10.1016/j.theriogenology.2014.12.019. PMID 25623231.

[pmid7841460-4] Harris JD, Hibler DW, Fontenot GK, Hsu KT, Yurewicz EC, Sacco AG (Mar 1995). "Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families". DNA Sequence. 4 (6): 361–93. doi:10.3109/10425179409010186. PMID 7841460.

[entrez-5] "Entrez Gene: ZP4 zona pellucida glycoprotein 4".

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