Zeke is a masculine given name or nickname.
Zeke may also refer to:
- Zeke, Allied code name for the Mitsubishi A6M Zero Japanese World War II fighter
- Tropical Storm Zeke, two typhoons and a tropical storm, all in the early 1990s
- Zeke, Burkina Faso, a village
- Zeke (band), an American hardcore punk band
- Zero electron kinetic energy spectroscopy, a form of high resolution photoelectron spectroscopy
- Zeke, an artificial intelligence agent in development by Hub Culture
- Big Zeke, a ring name of retired professional wrestler Ezekiel Jackson (born 1978)
- Zeek Braverman, a character in the TV series Parenthood