Zinc transporter ZIP1

SLC39A1
Identifiers
Aliases	SLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDs	OMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,968,184 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,160,919 bp
RNA expression pattern
	Top expressed in
	placenta; ; Achilles tendon; ; upper lobe of left lung; ; right lung; ; stromal cell of endometrium; ; gallbladder; ; right adrenal gland; ; left adrenal gland; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	prostate; ; umbilical cord; ; epidermis; ; lip; ; uterus; ; placenta; ; urinary bladder; ; gallbladder; ; duodenum; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity; inorganic cation transmembrane transporter activity; zinc ion transmembrane transporter activity; signaling receptor binding;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	embryonic cranial skeleton morphogenesis; metal ion transport; zinc ion transmembrane transport; cation transport; zinc ion transport; in utero embryonic development; ion transport; limb development; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	27173
	30791
	ENSG00000143570
	ENSMUSG00000052310
	Q9NY26
	Q9QZ03
NM_014437; NM_001271957; NM_001271958; NM_001271959; NM_001271960;
	NM_001271961
	NM_013901
NP_001258886; NP_001258887; NP_001258888; NP_001258889; NP_001258890;
	NP_055252
	NP_038929
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.^[5]^[6]^[7]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610721-5] Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.

[pmid10681536-6] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.

[entrez-7] "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".

[pmid16700911-8] Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

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