| 1921 Buffalo All-Americans season | |
|---|---|
| Head coach | Tommy Hughitt |
| Home field | Canisius College |
| Results | |
| Record | 10–1–2 Overall 9–1–2 APFA |
| Division place | 2nd APFA |
| Playoff finish | Lost 10–7 to Chicago Staleys |
The 1921 Buffalo All-Americans season was their second completed in the young American Professional Football Association (APFA). The team matched their previous output of 9–1–1, going 9–1–2 against league opponents, and losing the league title to the Chicago Staleys in a disputed tiebreaker.[1]