1921 Cal Poly Mustangs football team

1921 Cal Poly Mustangs football
ConferenceIndependent
Record3–2–1
Head coach
Seasons
← 1920
1922 →

The 1921 Cal Poly Mustangs football team represented California Polytechnic School—now known as California Polytechnic State University, San Luis Obispo—as an independent during the 1921 college football season. Led by first-year head coach Al Agosti, Cal Poly compiled a record of 3–2–1 outscored their opponents 107 to 48.

Cal Poly was a two-year school until 1941.