The 1922 Guayaquil general strike was a three-day general work stoppage in the city of Guayaquil, Ecuador, which lasted from 13 to 15 November of that year. The strike began with trolley, electric company and other public utility workers who were inspired by a successful strike by railroad workers in nearby Durán. Workers made demands such as pay increases, shorter hours, safer working conditions, and government control of foreign currency exchange rates.
The government of Ecuador called on the military to suppress the strike. On 15 November 1922, police and military killed at least 300 strikers. Most workers returned to their jobs shortly afterwards. The trolley workers continued their strike until 21 November, when most of their demands were met.