The 1941 All-Southern Conference football team consists of American football players chosen by the Associated Press (AP) and United Press (UP) for the All-Southern Conference football team for the 1941 college football season.
The 1941 Duke Blue Devils football team won the Southern Conference championship, was ranked No. 2 in the final AP Poll, and placed four players on the first team: back Steve Lach (AP-1, UP-1), end Bob Gantt (AP-1, UP-2); tackle Mike Karmazin (AP-1, UP-1); and center Bob Barnett (AP-1, UP-1).