| 1945 Southwestern Pirates football | |
|---|---|
| Conference | Texas Conference |
| Record | 2–6–1 (0–0 Texas) |
| Head coach |
|
| Captain | Ed J. "Blotz" Blodzinski |
The 1945 Southwestern Pirates football team represented Southwestern University during the 1945 college football season. Led by seventh-year head coach Randolph M. Medley, the Pirates compiled a record of 2–6–1.