| Little Three | |
|---|---|
| Sport | Football |
| Number of teams | 3 |
| Champion | Wesleyan |
The 1946 Little Three Conference football season was the season of college football played by the three member schools of the Little Three Conference as part of the 1946 college football season.
The Wesleyan Cardinals won the Little Three championship with a perfect 7–0 record and outscored opponents by a total of 165 to 29.