| Tournament details | |
|---|---|
| Country | Venezuela |
| City | Caracas |
| Venue(s) | 1 (in 1 host city) |
| Dates | 22–26 February |
| Teams | 4 |
| Final positions | |
| Champions |  Cangrejeros de Santurce (1st title) |
| Runner-up |  Leones del Habana |
| Tournament statistics | |
| MVP | Luis Olmo |
The third edition of the Caribbean Series (Serie del Caribe) was played in 1951. The Series inauguration on February 21 was delayed due to heavy rain and it was held from February 22 through February 26, including two double-headers on February 25, featuring the champion baseball teams of Cuba, Leones del Habana; Panama, Spur Cola Colonites; Puerto Rico, Cangrejeros de Santurce, and Venezuela, Navegantes del Magallanes. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Cervecería Caracas Stadium in Caracas, Venezuela.