| Tournament details | |
|---|---|
| Country | Panama |
| City | Panama City |
| Venue(s) | 1 (in 1 host city) |
| Dates | 20–26 February |
| Teams | 4 |
| Final positions | |
| Champions |  Leones del Habana (1st title) |
| Runner-up |  Carta Vieja Yankees |
| Tournament statistics | |
| MVP |  Tommy Fine |
The fourth edition of the Caribbean Series (Serie del Caribe) was played in 1952. It was held from February 20 through February 26, featuring the champion baseball teams of Cuba, Leones del Habana; Panama, Carta Vieja Yankees; Puerto Rico, Senadores de San Juan and Venezuela, Cervecería Caracas. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Panama City. The first pitch was thrown by Alcibíades Arosemena, by then the President of Panama.