The 1958 12-Hour Florida International Grand Prix of Endurance for the Amoco Trophy took place on 22 March, on the Sebring International Raceway, (Florida, United States). It was the second round of the F.I.A. World Sports Car Championship, which was running to new regulations introduced at the beginning of the season. The most influential of these regulations changes would be the 3.0 litre engine size limit. This was seventh running of the 12-hour race.