The 1963 Luton by-election was held on 7 November 1963 following the resignation of the former "radio doctor" and Conservative Minister Charles Hill. Hill had a majority of over 5,000 at the 1959 general election, but the Luton seat was won by the Labour candidate Will Howie with a majority of 3,749.
| Party | Candidate | Votes | % | ±% | |
|---|---|---|---|---|---|
| Labour | William Howie | 21,108 | 48.02 | +3.11 | |
| Conservative | John Fletcher-Cooke | 17,359 | 39.49 | −15.60 | |
| Liberal | Malvyn A Benjamin | 5,001 | 11.38 | N/A | |
| Communist | Tony Chater | 490 | 1.11 | New | |
| Majority | 3,749 | 8.53 | N/A | ||
| Turnout | 43,958 | ||||
| Labour gain from National Liberal | Swing | ||||