The 1968 United States House of Representatives elections in South Carolina were held on November 5, 1968, to select six Representatives for two-year terms from the state of South Carolina. The primary elections were held on June 11 and the runoff elections were held two weeks later on June 25. All five incumbents who ran were re-elected and the open seat in the 5th district was retained by the Democrats. The composition of the state delegation remained five Democrats and one Republican.