The sixteenth edition of the Caribbean Series (Serie del Caribe) was played in 1973. It was held from February 1 through February 6 with the champions teams from Dominican Republic (Tigres del Licey), Mexico (Yaquis de Obregón), Puerto Rico (Cangrejeros de Santurce) and Venezuela (Leones del Caracas). The format consisted of 12 games, each team facing the other teams twice, and the games were played at UCV Stadium in Caracas, Venezuela. The Series was played to honor the memory of Roberto Clemente, who died on December 31, 1972, during a humanitarian mission to assist victims of the 1972 Nicaragua earthquake.