The already embattled incumbent Democratic president Carter was hurt in the state by the strong third party candidacy of John B. Anderson, a liberal Republican Congressman who ran in 1980 as an independent after failing to win the Republican Party's own presidential nomination. Anderson proved very popular with liberal and moderate voters in New England who normally leaned Democratic but were dissatisfied with the policies of the Carter administration and viewed Reagan as too far to the right. New England overall would prove to be Anderson's strongest region in the nation, with all six New England states giving double-digit percentages to Anderson. However, Maine would prove to be Anderson's weakest state in New England with only 10.20% of the popular vote, whereas all five of the other states in New England gave Anderson over 12% of the popular vote, peaking at 15.15% in Massachusetts.
Along with Michigan, New York, Mississippi and Vermont, Maine was one of the few states in which President Carter won counties that had gone to Ford in the previous presidential election, as Carter flipped Cumberland County. As a result, Reagan was the first Republican to ever win a presidential election without this county. This was the last presidential election in which Hancock County was the most Republican county in Maine.