The 1999 2. divisjon was the third highest football league for men in Norway.
22 games were played in 8 groups, with 3 points given for wins and 1 for draws. Hamarkameratene, Sandefjord, Strindheim and Tromsdalen were promoted to the First Division through playoffs against the other 4 group winners. Number twelve, thirteen and fourteen were relegated to the 3. divisjon. The winning teams from each of the 19 groups in the 3. divisjon, and some number-two teams, were promoted to the 2. divisjon.