2-Butoxyethanol

2-Butoxyethanol
2-Butoxyethanol
2-Butoxyethanol molecule
Names
Preferred IUPAC name
2-Butoxyethanol
Other names
2-Butoxyethanol
Butyl cellosolve
Butyl glycol
Butyl monoether glycol
EGBE (ethylene glycol monobutyl ether)
Dowanol EB
Eastman EB solvent
2-BE
EGMBE
Butyl oxitol
Ektasolve EB
Jeffersol EB
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.003.550 Edit this at Wikidata
EC Number
  • 203-905-0
RTECS number
  • KJ8575000
UNII
UN number 1993, 2810, 2369
  • InChI=1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3 ☒N
    Key: POAOYUHQDCAZBD-UHFFFAOYSA-N ☒N
  • InChI=1/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3
    Key: POAOYUHQDCAZBD-UHFFFAOYAB
  • OCCOCCCC
Properties
C6H14O2
Molar mass 118.176 g·mol−1
Appearance Clear, colorless liquid
Density 0.90 g/cm3, liquid
Melting point −77 °C (−107 °F; 196 K)
Boiling point 171 °C (340 °F; 444 K)
Miscible (and in most organic solvents)
Vapor pressure 0.8 mmHg[1]
Acidity (pKa) High pKa for −OH group
1.4198 (20 °C)[2]
Viscosity 2.9 cP at 25 °C (77 °F)
2.08 D[2]
Hazards
GHS labelling:
GHS06: ToxicGHS07: Exclamation markGHS08: Health hazard
Danger
H227, H302, H311, H315, H319, H330, H336, H361, H370, H372
P201, P202, P210, P260, P261, P264, P270, P271, P280, P281, P284, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 2: Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur. Flash point between 38 and 93 °C (100 and 200 °F). E.g. diesel fuelInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2
2
0
Flash point 67 °C (153 °F; 340 K)
245 °C (473 °F; 518 K)
Explosive limits 1.1–12.7%[1]
Lethal dose or concentration (LD, LC):
1230 mg/kg (mouse, oral)
470 mg/kg (rat, oral)
300 mg/kg (rabbit, oral)
1200 mg/kg (guinea pig, oral)
1480 mg/kg (rat, oral)[3]
450 ppm (rat, 4 hr)
700 ppm (mouse, 7 hr)[3]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 50 ppm (240 mg/m3) [skin][1]
REL (Recommended)
 TWA 5 ppm (24 mg/m3) [skin][1]
IDLH (Immediate danger)
 700 ppm[1]
Safety data sheet (SDS) [1]
Related compounds
Related ethers
 2-Methoxyethanol
2-Ethoxyethanol
Related compounds
 Ethylene glycol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH (Bu = CH3CH2CH2CH2). This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. It is a known respiratory irritant[4] and can be acutely toxic, but animal studies did not find it to be mutagenic, and no studies suggest it is a human carcinogen.[5] A study of 13 classroom air contaminants conducted in Portugal reported a statistically significant association with increased rates of nasal obstruction and a positive association below the level of statistical significance with a higher risk of obese asthma and increased body mass index.[6]

  1. ^ a b c d e NIOSH Pocket Guide to Chemical Hazards. "#0070". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ a b William M. Haynes, ed. (2016). CRC handbook of chemistry and physics : a ready-reference book of chemical and physical data (97th ed.). Boca Raton, Florida: CRC Press. ISBN 978-1-4987-5428-6. OCLC 930681942.
  3. ^ a b "2-Butoxyethanol". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  4. ^ "Toxnet Has Moved". www.nlm.nih.gov. Retrieved 2020-01-24.
  5. ^ "Public Health Statement for 2-Butoxyethanol and 2-Butoxyethanol Acetate". Agency for Toxic Substances and Disease Registry, Center for Disease Control. August 1998. Retrieved 16 February 2020.
  6. ^ Paciência, Inês; Cavaleiro Rufo, João; Silva, Diana; Martins, Carla; Mendes, Francisca; Farraia, Mariana; Delgado, Luís; De Oliveira Fernandes, Eduardo; Padrão, Patrícia; Moreira, Pedro; Severo, Milton; Barros, Henrique; Moreira, André (2019). "Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity". Allergy. 74 (7): 1277–1291. doi:10.1111/all.13740. PMID 30740706. S2CID 73443692.